Nijmegen Breakage Syndrome

What is Nijmegen breakage syndrome? Nijmegen (pronounced “NY-may-gen”) breakage syndrome is a rare genetic disorder. It is characterized by developmental delay, recurring infections, and an increased risk of cancer. A person must have two variants in the NBN gene in order to have this condition. People with just one variant in the NBN gene are… Continue reading Nijmegen Breakage Syndrome

Hereditary Fructose Intolerance

What is hereditary fructose intolerance? Hereditary fructose intolerance is a rare genetic disorder. It is characterized by low blood sugar levels, stomach pain, and vomiting after eating fructose (a type of sugar). A person must have two variants in the ALDOB gene in order to have this condition. People with just one variant in the… Continue reading Hereditary Fructose Intolerance

ARSACS

What is ARSACS? ARSACS (also known as autosomal recessive spastic ataxia of Charlevoix-Saguenay) is a rare genetic disorder characterized by loss of sensation and muscle control, as well as muscle stiffness that worsens over time. A person must have two variants in the SACS gene in order to have this condition. People with just one… Continue reading ARSACS

Salla Disease

What is Salla disease? Salla disease (also known as free sialic acid storage disease) is a rare genetic disorder. It is characterized by a gradual loss of muscle tone and coordination, as well as impaired growth, intellectual disability, and seizures. A person must have two variants in the SLC17A5 gene in order to have this… Continue reading Salla Disease

Pyruvate Kinase Deficiency

What is pyruvate kinase (PK) deficiency? Pyruvate kinase (PK) deficiency is a rare genetic disorder in which red blood cells break down too quickly, leading to chronic anemia. A person must have two variants in the PKLR gene, or two copies of a variant, in order to have this condition. People with just one variant… Continue reading Pyruvate Kinase Deficiency

Sjögren-Larsson Syndrome

What is Sjögren-Larsson syndrome? Sjögren-Larsson syndrome is a rare genetic disorder characterized by scaly dry skin, intellectual disability, and persistent muscle stiffness. A person must have two variants in the ALDH3A2 gene in order to have this genetic condition. People with just one variant in the ALDH3A2 gene are called carriers. They’re not expected to… Continue reading Sjögren-Larsson Syndrome

MCAD Deficiency

What is MCAD deficiency?  MCAD Deficiency is a rare genetic disorder characterized by episodes of very low blood sugar while fasting or under stress. A person must have two variants in the ACADM gene in order to have this genetic condition. People with just one variant in the ACADM gene are called carriers. They’re not… Continue reading MCAD Deficiency